Metafolin is a trademarked name for the active form of folate, known as methylfolate. While Optimized Folate doesn't utilize this specific brand, it does include L-Methylfolate.

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Life Extension

Q: It says 1700 mcf DFE of folate, but how of that is actual folic acid equivalent?

Hello, We apologize for any confusion. At the end of August of 2020, we updated our Optimized Folate supplement facts section. The amount of folate was updated from 1,000 mcg to 1,700 mcg based on updated FDA labeling guidelines. This change is a result of what the FDA has defined as dietary folate equivalents (DFE). They determined that 0.6 mcg of (6S)-5-methyltetrahydrofolate, calcium salt is equal to 1 mcg DFE. They have also determined that one mcg of naturally occurring folate is equal to one mcg DFE. Their rationale is that this accounts for the greater bioavailability (6S)-5-methyltetrahydrofolate, calcium salt compared to naturally occurring folate. The change to 1,700 mcg in this product allows us to deliver the desired potency in terms of DFE.

Q: What is the expiration date?

The expiration date on mine is 7/20/2023, but I bought it over 3 months ago. I have no idea what the expiration date will be on the bottle you’re buying.

Q: Is any component of your usa manufactured product sourced from china or india?

It's been a very long time since I purchased this product. I no longer have the container and have consumed all of the product. That said, I have since switched to Folic Acid 800 mcg made in Austin Texas and available on Amazon.

Product ID: 15690762

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Details

Brand
Life Extension
Item Form
Tablet
Primary Supplement Type
Folate [as
Diet Type
Vegetarian
Flavor
Unflavored

⚡Metabolically active folate form

🧠1700 mcg 5-MTHF for brain boost

❤️Supports healthy homocysteine levels

Frequently Bought Together

Life Extension Optimized Folate – L-methylfolate – Heart & Brain Support, Healthy Homocysteine Levels – Non-GMO, Gluten-Free, Vegetarian – 1700 mcg DFE, 100 Vegetarian Tablets

Life Extension TMG 500 mg – Trimethylglycine Supplement – Encourages Healthy Homocysteine Levels – Gluten-free – Non-gmo – Vegetarian – 60 Liquid Vegetarian Capsules

Life Extension Neuro-Mag Magnesium L-Threonate, Magnesium L-threonate, Memory Health, Quick Thinking, Cognitive Health Support, Vegetarian, Non-GMO, 90 Vegetarian Capsules

Description

🧬 Unlock your brain & heart’s full potential—because aging is optional.

HEART HEALTH HERO - Clinically-backed folate formula helps maintain normal homocysteine levels, supporting your cardiovascular resilience.
PURE POTENT PROMISE - Non-GMO, gluten-free, USA-made with transparent Certificates of Analysis—because quality is non-negotiable.
SCIENCE DRIVEN WELLNESS - Formulated on cutting-edge research to empower your healthiest, most productive self every day.
READY TO USE FOLATE POWER - Bypasses conversion hurdles with 5-MTHF, ensuring maximum absorption and effectiveness for every body.
COGNITIVE CLARITY ELEVATED - 1700 mcg of bioactive 5-MTHF fuels sharper focus and memory, perfect for staying ahead in any boardroom.

Life Extension delivers 1700 mcg of 5-MTHF, the metabolically active form of folate, to support optimal cognitive function and maintain healthy homocysteine levels for cardiovascular health. This non-GMO, gluten-free supplement is manufactured in the USA with rigorous quality standards, designed to enhance brain and heart wellness backed by scientific research.

Have a Question? See What Others Asked

It says 1700 mcf DFE of folate, but how of that is actual folic acid equivalent?

What is the expiration date?

Is this Metafolin?

Is any component of your usa manufactured product sourced from china or india?

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